629plapatinib versus Lapatinib plus Capecitabine as Second-line Treatment in Her2-overexpressing Metastatic Gastro-esophageal Cancer (gc): a Randomized Phase Ii Trial of the Arbeitsgemeinschaft Internistische Onkologie (aio).

نویسندگان

  • S Lorenzen
  • U Helbig
  • J Riera-Knorrenschild
  • G M Haag
  • M Pohl
  • P C Thuss-Patience
  • F Bassermann
  • F Weißinger
  • E Schnoy
  • K Becker
  • J Rüschoff
  • A Eisenmenger
  • I Karapanagiotou-Schenkel
  • F Lordick
چکیده

S. Lorenzen1, U. Helbig2, J. Riera-Knorrenschild3, G.M. Haag4, M. Pohl5, P. C. Thuss-Patience6, F. Bassermann1, F. Weißinger7, E. Schnoy8, K. Becker9, J. Rüschoff10, A. Eisenmenger11, I. Karapanagiotou-Schenkel11, F. Lordick12 3rd Department of Internal Medicine (hematology/medical Oncology), Klinikum Rechts der Isar, Technische Universität München, Munich, GERMANY 3rd Medical Department, Hematology and Oncology, Klinikum Braunschweig, Braunschweig, GERMANY Clinic for Hematology, Oncology and Immunology, Universitaetsklinikum Giessen und Marburg, Marburg, GERMANY Department of Medical Oncology, National Center for Tumor Diseases, University Hospital Heidelberg, Heidelberg, GERMANY Department of Medicine, Knappschaftskrankenhaus, Ruhr University Bochum, Bochum, GERMANY Department of Hematology, Oncology and Tumor Immunology, Virchow-Klinikum, Charité, Berlin, Berlin, GERMANY Department of Medicine, Hematology, Oncology and Palliative Care, Evangelisches Krankenhaus, Bielefeld, Bielefeld, GERMANY Department of Internal Medicine, University Clinic Regensburg, Regensburg, GERMANY Onkologische Praxis, Lerchenfeld, Hamburg, GERMANY Molecular Pathology, Targos, Kassel, GERMANY NCT Trial Center, National Center for Tumor Diseases, Heidelberg, Heidelberg, GERMANY University Cancer Center Leipzig, University of Leipzig, Leipzig, GERMANY

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Lapatinib versus lapatinib plus capecitabine as second-line treatment in human epidermal growth factor receptor 2-amplified metastatic gastro-oesophageal cancer: a randomised phase II trial of the Arbeitsgemeinschaft Internistische Onkologie.

INTRODUCTION Human epidermal growth factor receptor 2 (HER2) amplification is present in a subgroup of gastroo-esophageal cancers (GCs). HER2 inhibition with trastuzumab has shown to improve outcomes in advanced disease. Lapatinib ditosylate (LAP), a dual anti-epidermal growth factor receptor (EGFR) and anti-HER2 tyrosine kinase inhibitor with preclinical activity against GC, has been approved ...

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OBJECTIVE AIO-PK0104 investigated two treatment strategies in advanced pancreatic cancer (PC): a reference sequence of gemcitabine/erlotinib followed by 2nd-line capecitabine was compared with a reverse experimental sequence of capecitabine/erlotinib followed by gemcitabine. METHODS 281 patients with PC were randomly assigned to 1st-line treatment with either gemcitabine plus erlotinib or cap...

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Current oncological treatment of patients with pancreatic cancer in germany: results from a national survey on behalf of the Arbeitsgemeinschaft Internistische Onkologie and the Chirurgische Arbeitsgemeinschaft Onkologie of the Germany Cancer Society.

BACKGROUND No data have previously been available regarding the current treatment of patients with pancreatic cancer (PC) in German hospitals and medical practices. METHODS Between February 2007 and March 2008 we conducted a national survey [on behalf of the Arbeitsgemeinschaft Internistische Onkologie (AIO) and the Chirurgische Arbeitsgemeinschaft Onkologie (CAO)] regarding the current surgi...

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REFERENCES 1. Amir E, Seruga B, Freedman O, et al: Lapatinib plus paclitaxel as first-line therapy for patients with human epidermal growth factor receptor 2–positive metastatic breast cancer: inappropriate conclusions from a company-sponsored study? J Clin Oncol 27:1919, 2009 2. Di Leo A, Gomez HL, Aziz Z, et al: Phase III, double-blind, randomized study comparing lapatinib plus paclitaxel wit...

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BACKGROUND Lapatinib in combination with capecitabine is approved for the treatment of patients with advanced or metastatic breast cancer whose tumors overexpress the human epidermal growth factor receptor 2 (HER2) and who have received prior therapy including an anthracycline, a taxane, and trastuzumab. Based on our phase I trial, we conducted a single arm, multicenter phase II study of lapati...

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عنوان ژورنال:
  • Annals of oncology : official journal of the European Society for Medical Oncology

دوره 25 suppl_4  شماره 

صفحات  -

تاریخ انتشار 2014